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Lexapro is an oral drug that is indicated for treating depression and generalized anxiety disorder. Chemically, escitalopram is similar to the drug citalopram. Both are in the class of drugs called selective serotonin reuptake inhibitors, a class that also includes fluoxetine, paroxetine and sertraline SSRIs work by affecting neurotransmitters in the brain, the chemical impulses that nerves use to communicate with one another. Neurotransmitters are distributed and made by nerves and then travel to other nearby nerves where they attach to receptors on the nerves. Some neurotransmitters that are distributed do not bind to receptors and are taken up by the nerves that produced them. Many experts believe that an imbalance of neurotransmitters is the root cause of depression. This drug prevents the reuptake of one neurotransmitter, serotonin, by nerves, an action which results in more serotonin in the brain to attach to receptors. The Food and Drug Administration approved escitalopram in August 2002.
Lexapro is approved for the treatment of depression and generalized anxiety disorder. Drugs in the SSRI class also have been studied in persons with panic disorders, obsessive compulsive disorders but escitalopram is not approved for this purpose.
The usual recommended starting dose of Lexapro is 10 mg once daily in the morning or evening. The dose may be increased to 20 mg once daily after 1 week and benefit may not be seen until treatment has been given for up to 4 weeks. A daily dose of 20 mg may not be anymore effective than 10 mg daily for cure for depression.
All SSRIs, including this drug, should not be combined with drugs in the monoamine oxidase inhibitor class of antidepressants such as isocarboxazid, phenelzine, tranylcypromine, selegiline and procarbazine. Such combinations may lead to high fevers,confusion, high blood pressure, high fevers, tremor or muscle rigidity, and increased activity. At least 14 days should elapse after discontinuing this drug before starting an MAO inhibitor. Conversely, at least 14 days should elapse after discontinuing an MAO inhibitor before starting Lexapro.
Tryptophan may cause headaches, sweating, nausea and dizziness when taken with any SSRI.
Use of selective SSRI may increase the risk of gastrointestinal bleeding in patients taking aspirin, nonsteroidal antiinflammatory drugs, and other drugs that cause bleeding.